Cristiano Ronaldo become the joint-top goalscorer in World Cup qualifying history in Portugal's 3-2 triumph at Hungary on Tuesday.
The Portugal captain scored from the penalty spot to net his 39th goal in World Cup qualifying and join Guatemala's Carlos Ruiz as the highest scorer.
He found the net twice in Portugal's 5-0 win at Armenia in Saturday's World Cup qualifier.
"Two games, two wins, let's go Portugal," Ronaldo said on Instagram.
The Al Nassr forward could overtake Ruiz, who retired from football in 2016, when Portugal resume qualifying on Oct. 11 against Ireland.
Messi, who was rested in Argentina's 1-0 loss at Ecuador in their final World Cup qualifier on Tuesday, finished with eight goals -- one ahead of Colombia's Luis Díaz and Bolivia's Miguel Terceros.
He is three goals behind Ronaldo and Ruiz in the all-time standings.
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Argentina's captain struck twice in last week's 3-0 triumph against Venezuela in Buenos Aires in what was is expected to be his final competitive match on home soil.
Messi, 38, has scored a record 114 goals in 194 games for his country. Ronaldo is the highest scorer in men's international football with 141 goals in 223 appearances for Portugal.
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